Controlling cell-cell interactions using surface acoustic waves.

ABSTRACT: The interactions between pairs of cells and within multicellular assemblies are critical to many biological processes such as intercellular communication, tissue and organ formation, immunological reactions, and cancer metastasis. The ability to precisely control the position of cells relative to one another and within larger cellular assemblies will enable the investigation and characterization of phenomena not currently accessible by conventional in vitro methods. We present a versatile surface acoustic wave technique that is capable of controlling the intercellular distance and spatial arrangement of cells with micrometer level resolution. This technique is, to our knowledge, among the first of its kind to marry high precision and high throughput into a single extremely versatile and wh

SUBMITTER: Guo F 

PROVIDER: S-EPMC4291613 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature