A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.

ABSTRACT: Glucocorticoids are known to promote the development of metabolic syndrome through the modulation of both feeding pathways and metabolic processes; however, the precise mechanisms of these effects are not well-understood. Recent evidence shows that glucocorticoids possess the ability to increase endocannabinoid signaling, which is known to regulate appetite, energy balance, and metabolic processes through both central and peripheral pathways. The aim of this study was to determine the role of endocannabinoid signaling in glucocorticoid-mediated obesity and metabolic syndrome. Using a mouse model of excess corticosterone exposure, we found that the ability of glucocorticoids to increase adiposity, weight gain, hormonal dysregulation, hepatic steatosis, and dyslipidemia was reduced or revers

SUBMITTER: Bowles NP 

PROVIDER: S-EPMC4291642 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature