Chemically synthesized molecules with the targeting and effector functions of antibodies.

ABSTRACT: This article reports the design, synthesis, and evaluation of a novel class of molecules of intermediate size (approximately 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds—called synthetic antibody mimics targeting prostate cancer (SyAM-Ps)—bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis. SyAMs have the potential to combine the advantages of both small-molecule and biologic therapies, and may address many drawbacks associated with available treatments for cancer and other diseases.

SUBMITTER: McEnaney PJ 

PROVIDER: S-EPMC4291750 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature