Metabolic engineering of Escherichia coli for the synthesis of the plant polyphenol pinosylvin.

ABSTRACT: Plant polyphenols are of great interest for drug discovery and drug development since many of these compounds have health-promoting activities as treatments against various diseases, such as diabetes, cancer, or heart diseases. However, the limited availability of polyphenols represents a major obstacle to clinical applications that must be overcome. In comparison to the quantities of these compounds obtained by isolation from natural sources or costly chemical synthesis, the microbial production of these compounds could provide sufficient quantities from inexpensive substrates. In this work, we describe the development of an Escherichia coli platform strain for the production of pinosylvin, a stilbene found in the heartwood of pine trees which could aid in the treatment of various cancers

SUBMITTER: van Summeren-Wesenhagen PV 

PROVIDER: S-EPMC4292501 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature