Approaching a network connectivity-driven classification of the psychosis continuum: a selective review and suggestions for future research.

ABSTRACT: Brain changes in schizophrenia evolve along a dynamic trajectory, emerging before disease onset and proceeding with ongoing illness. Recent investigations have focused attention on functional brain interactions, with experimental imaging studies supporting the disconnection hypothesis of schizophrenia. These studies have revealed a broad spectrum of abnormalities in brain connectivity in patients, particularly for connections integrating the frontal cortex. A critical point is that brain connectivity abnormalities, including altered resting state connectivity within the fronto-parietal (FP) network, are already observed in non-help-seeking individuals with psychotic-like experiences. If we consider psychosis as a continuum, with individuals with psychotic-like experiences at the lower and

SUBMITTER: Schmidt A 

PROVIDER: S-EPMC4292722 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature