Renal function and klotho gene polymorphisms among Uygur and Kazak populations in Xinjiang, China.

ABSTRACT:

Background

The association of genetic polymorphisms of klotho gene with aging has not been thoroughly examined. Previous studies showed that longevity in the Uygurs was considerably greater than in Kazaks in Xinjiang. This study aimed to investigate the difference of renal function and Klotho gene polymorphisms between Kazak and Uygur normal populations in Xinjiang, China.

Material/methods

A total of 249 Uygur and 386 Kazak clinically normal subjects were included in this study. Four single-nucleotide polymorphisms (rs1207568, rs564481, rs9527025, and rs9536314) of the klotho gene were genotyped using the ABI SNaPshot method. Estimated glomerular filtration rate (eGFR) was calculated according to the Chinese simplified MDRD equation.

Results

There were significant dif

SUBMITTER: Xu X 

PROVIDER: S-EPMC4292765 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature