Enlargement of thalamic nuclei in Tourette syndrome.

ABSTRACT:

Context

The basal ganglia and thalamus together connect in parallel closed-loop circuits with the cortex. Previous imaging studies have shown modifications of the basal ganglia and cortical targets in individuals with Tourette syndrome (TS), but less is known regarding the role of the thalamus in TS pathogenesis.

Objective

To study the morphological features of the thalamus in children and adults with TS.

Design

A cross-sectional, case-control study using anatomical magnetic resonance imaging.

Setting

University research center.

Participants

The 283 participants included 149 with TS and 134 normal control individuals aged 6 to 63 years.

Main outcome measures

Conventional volumes and measures of surface morphology of the thalamus.

Results

An

SUBMITTER: Miller AM 

PROVIDER: S-EPMC4292904 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature