Recent advances on the δ opioid receptor: from trafficking to function.

ABSTRACT:

Unlabelled

Within the opioid family of receptors, δ (DOPrs) and μ opioid receptors (MOPrs) are typical GPCRs that activate canonical second-messenger signalling cascades to influence diverse cellular functions in neuronal and non-neuronal cell types. These receptors activate well-known pathways to influence ion channel function and pathways such as the map kinase cascade, AC and PI3K. In addition new information regarding opioid receptor-interacting proteins, downstream signalling pathways and resultant functional effects has recently come to light. In this review, we will examine these novel findings focusing on the DOPr and, in doing so, will contrast and compare DOPrs with MOPrs in terms of differences and similarities in function, signalling pathways, distribution and interacti

SUBMITTER: Gendron L 

PROVIDER: S-EPMC4292956 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature