Comparative efficiency research (COMER): meta-analysis of cost-effectiveness studies.

ABSTRACT:

Background

The aim of this study was to create a new meta-analysis method for cost-effectiveness studies using comparative efficiency research (COMER).

Methods

We built a new score named total incremental net benefit (TINB), with inverse variance weighting of incremental net benefits (INB). This permits determination of whether an alternative is cost-effective, given a specific threshold (TINB > 0 test). Before validation of the model, the structure of dependence between costs and quality-adjusted life years (QoL) was analysed using copula distributions. The goodness-of-fit of a Spanish prospective observational study (n = 498) was analysed using the Independent, Gaussian, T, Gumbel, Clayton, Frank and Placket copulas. Validation was carried out by simulating a copula distri

SUBMITTER: Crespo C 

PROVIDER: S-EPMC4292992 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature