Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals.

ABSTRACT:

Importance

Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming secondary prevention trials using cognitive outcomes.

Objective

To determine whether neuroimaging markers of β-amyloid (Aβ) and neurodegeneration (ND) are independently or synergistically associated with longitudinal cognitive decline in CN individuals.

Design, setting, and participants

Academic medical center longitudinal natural history study among 166 CN individuals (median age, 74 years; 92 women).

Main outcomes and measures

The Aβ status was determined with Pittsburgh Compound B-positron emission tomography, while ND was assessed using 2 a priori measures, hippocampus volume (ma

SUBMITTER: Mormino EC 

PROVIDER: S-EPMC4293023 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature