Injectable gelatin derivative hydrogels with sustained vascular endothelial growth factor release for induced angiogenesis.

ABSTRACT: Injectable biomaterials are attractive for soft tissue regeneration because they are handled in a minimally invasive manner and can easily adapt to complex defects. However, inadequate vascularization of the injectable constructs has long been a barrier, leading to necrosis or volume reduction after implantation. In this work, we developed a three-step process to synthesize injectable gelatin-derived hydrogels that are capable of controlling growth factor delivery to induce angiogenesis. In our approach, tyramine was first introduced into gelatin chains to provide enzymatic crosslinking points for gel formation after injection. Next, heparin, a polysaccharide with binding domains to many growth factors, was covalently linked to the tyramine-modified gelatin. Finally, vascular endothelial g

SUBMITTER: Li Z 

PROVIDER: S-EPMC4293253 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature