Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis.

ABSTRACT:

Background & aims

A greater understanding of cholestatic disease is necessary to advance diagnostic tools and therapeutic options for conditions such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The purpose of this study was to determine and compare the serum metabolomes of patients with PBC (n = 18) or PSC (n = 21) and healthy controls (n = 10) and to identify metabolites that may differentiate these two cholestatic diseases.

Methods and results

Using a mass spectrometry-based, non-targeted biochemical profiling approach, we identified 420 serum metabolites, 101 that differed significantly (P ≤ 0.05) between PBC and control groups, 115 that differed significantly between PSC and control groups, and 56 that differed significantly between PSC a

SUBMITTER: Bell LN 

PROVIDER: S-EPMC4293304 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature