Mitochondrial ATPase subunit 6 and cytochrome B gene variations in obese Turkish children.

ABSTRACT:

Objective

Due to the importance of energy metabolism in mitochondria, mitochondrial genome variations are evaluated in energy-related diseases such as obesity. To date, several nuclear genes were found to be related to obesity. Our aim in this study was to investigate the presence of polymorphisms in mitochondrial ATPase subunit 6 (mt-ATP6) and cytochrome b (mt-CytB) genes that may be associated with childhood obesity.

Methods

The mt-ATP6 and mt-CytB genes were amplified and entirely sequenced in a series of 100 obese and in an equal number of healthy Turkish children aged between 6-14 years.

Results

A total of 118 synonymous and nonsynonymous variations were detected in the obese and control groups. Only two previously reported synonymous substitutions (mt.8614T>C an

SUBMITTER: Demir D 

PROVIDER: S-EPMC4293655 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature