B-type natriuretic peptides improve cardiovascular disease risk prediction in a cohort of women.

ABSTRACT:

Background

Although N-terminal pro-B-type natriuretic peptide (NT-proBNP) has a strong relationship with incident cardiovascular disease (CVD), few studies have examined whether NT-proBNP adds to risk prediction algorithms, particularly in women.

Objectives

This study sought to evaluate the relationship between NT-proBNP and incident CVD in women.

Methods

Using a prospective case-cohort within the WHI (Women's Health Initiative) observational study, we selected 1,821 incident cases of CVD (746 myocardial infarctions, 754 ischemic strokes, 160 hemorrhagic strokes, and 161 other cardiovascular [CV] deaths) and a randomly selected reference cohort of 1,992 women without CVD at baseline.

Results

Median levels of NT-proBNP were higher at study entry among incident c

SUBMITTER: Everett BM 

PROVIDER: S-EPMC4294182 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature