Joint effect of insulin signaling genes on all-cause mortality.

ABSTRACT:

Objective

We have previously reported the combined effect of SNPs perturbing insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on insulin resistance (IR), type 2 diabetes (T2D) and cardiovascular events. We here investigated whether such a combined effect affects also all-cause mortality in a sample of 1851 Whites of European ancestry.

Methods

We investigated a first sample of 721 patients, 232 deaths, 3389 person-years (py). Replication was assessed in two samples of patients with T2D: the Gargano Mortality Study (GMS) of 714 patients, 127 deaths, 5426 py and the Joslin Kidney Study (JKS) comprising 416 patients, 214 deaths, 5325 py.

Results

In the first sample, individuals carrying 1 or ≥ 2 risk alleles had 33% (p = 0.06) and 5

SUBMITTER: Menzaghi C 

PROVIDER: S-EPMC4294190 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature