IgG4 subclass-specific responses to Staphylococcus aureus antigens shed new light on host-pathogen interaction.

ABSTRACT: IgG4 responses are considered indicative for long-term or repeated exposure to particular antigens. Therefore, studying IgG4-specific antibody responses against Staphylococcus aureus might generate new insights into the respective host-pathogen interactions and the microbial virulence factors involved. Using a bead-based flow cytometry assay, we determined total IgG (IgGt), IgG1, and IgG4 antibody responses to 40 different S. aureus virulence factors in sera from healthy persistent nasal carriers, healthy persistent noncarriers, and patients with various staphylococcal infections from three distinct countries. IgGt responses were detected against all tested antigens. These were mostly IgG1 responses. In contrast, IgG4 antibodies were detected to alpha-toxin, chemotaxis inhibitory protein o

SUBMITTER: Swierstra J 

PROVIDER: S-EPMC4294233 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature