MDR1 polymorphisms and idiopathic nephrotic syndrome in Slovak children: preliminary results.

ABSTRACT:

Background

The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms 1236T>C, 2677T>G, and 3435T>C was studied in relation to susceptibility, demographics, and pathological characteristics, as well as their role in the therapeutic response (TR) to prednisone treatment in children with idiopathic nephrotic syndrome (INS).

Material/methods

The polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism method in 46 children with INS and in 100 healthy controls. Different genetic models (codominant, dominant, recessive, and overdominant) were used for testing of associations between polymorphisms and phenotypes.

Results

Statistical analysis showed a significantly increased chance of TR in children carrying 3435

SUBMITTER: Cizmarikova M 

PROVIDER: S-EPMC4294597 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature