Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors.
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ABSTRACT:
SUBMITTER: Sos ML
PROVIDER: S-EPMC4294625 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors.
Sos Martin L ML Levin Rebecca S RS Gordan John D JD Oses-Prieto Juan A JA Webber James T JT Salt Megan M Hann Byron B Burlingame Alma L AL McCormick Frank F Bandyopadhyay Sourav S Shokat Kevan M KM
Cell reports 20140807 4
Despite the development of potent RAF/mitogen-activated protein kinase (MAPK) pathway inhibitors, only a fraction of BRAF-mutant patients benefit from treatment with these drugs. Using a combined chemogenomics and chemoproteomics approach, we identify drug-induced RAS-RAF-MEK complex formation in a subset of BRAF-mutant cancer cells characterized by primary resistance to vemurafenib. In these cells, autocrine interleukin-6 (IL-6) secretion may contribute to the primary resistance phenotype via i ...[more]
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