Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways.

ABSTRACT:

Rationale

Although asthma is recognized as a heterogeneous disease associated with clinical phenotypes, the molecular basis of these phenotypes remains poorly understood. Although genomic studies have successfully broadened our understanding in diseases such as cancer, they have not been widely used in asthma studies.

Objectives

To link gene expression patterns to clinical asthma phenotypes.

Methods

We used a microarray platform to analyze bronchial airway epithelial cell gene expression in relation to the asthma biomarker fractional exhaled nitric oxide (FeNO) in 155 subjects with asthma and healthy control subjects from the Severe Asthma Research Program (SARP).

Measurements and main results

We first identified a diverse set of 549 genes whose expression corr

SUBMITTER: Modena BD 

PROVIDER: S-EPMC4294630 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature