CYP2C19 polymorphism increases the risk of endometriosis.

ABSTRACT:

Purpose

Estrogen metabolizing gene mutations can be associated with defective hormonal signaling leading to disease processes. Endometriosis is an estrogen dependent that can be influenced by defective signaling in the estrogen pathway.

Objectives

To evaluate the association of A/G 85952 CYP2C19 and A/G 937 HSD17B1 gene polymorphisms with endometriosis through the investigation of a large Brazilian sample of women with endometriosis and a fertile control group.

Methods

Five hundred women with endometriosis and 500 women without endometriosis were tested for CYP2C19 and HSD17B1 polymorphisms, by TaqMan Real Time PCR. The results were statistically analyzed by chi-square, logistic regression and tested for Hardy-Weinberg equilibrium.

Results

The comparison of gen

SUBMITTER: Christofolini DM 

PROVIDER: S-EPMC4294871 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature