Possible influence of menstrual cycle on lymphocyte X chromosome mosaicism.

ABSTRACT:

Purpose

Estrogens are known to selectively influence cell proliferation. Physiological variations of blood hormone concentration might play a role in regulating the level of X chromosome aneuploidy. In this study we observed the percentages of X aneuploid cells in standard lymphocyte cultures from blood samples obtained in relation to the menstrual cycle, noting whether collection occurred during either the follicular or the luteal phase.

Methods

A study consisting of 28 women with X mosaicism and recurrent pregnancy loss, and 28 age-matched healthy controls. Cytogenetic studies were carried out on peripheral blood samples according to standard procedures.

Results

A significant difference in the percentage of X aneuploidy was found in blood samples obtained during dif

SUBMITTER: Gersak K 

PROVIDER: S-EPMC4294879 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature