Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies.

ABSTRACT:

Background

Red meat intake has been associated with risk of colorectal cancer, potentially mediated through heterocyclic amines. The metabolic efficiency of N-acetyltransferase 2 (NAT2) required for the metabolic activation of such amines is influenced by genetic variation. The interaction between red meat intake, NAT2 genotype, and colorectal cancer has been inconsistently reported.

Methods

We used pooled individual-level data from the Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium. Red meat intake was collected by each study. We inferred NAT2 phenotype based on polymorphism at rs1495741, highly predictive of enzyme activity. Interaction was assessed using multiplicative interaction terms in multivariate-adjusted models.

Re

SUBMITTER: Ananthakrishnan AN 

PROVIDER: S-EPMC4294960 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature