Association of prostate cancer risk variants with gene expression in normal and tumor tissue.

ABSTRACT:

Background

Numerous germline genetic variants are associated with prostate cancer risk, but their biologic role is not well understood. One possibility is that these variants influence gene expression in prostate tissue. We therefore examined the association of prostate cancer risk variants with the expression of genes nearby and genome-wide.

Methods

We generated mRNA expression data for 20,254 genes with the Affymetrix GeneChip Human Gene 1.0 ST microarray from normal prostate (N = 160) and prostate tumor (N = 264) tissue from participants of the Physicians' Health Study and Health Professionals Follow-up Study. With linear models, we tested the association of 39 risk variants with nearby genes and all genes, and the association of each variant with canonical pathways using

SUBMITTER: Penney KL 

PROVIDER: S-EPMC4294966 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature