Cost-effectiveness of genotype testing for primary resistance in Brazil.

ABSTRACT:

Objective

HIV genotype-resistance testing can help identify more effective antiretroviral treatment (ART) regimens for patients, substantially increasing the likelihood of viral suppression and immune recovery. We sought to evaluate the cost-effectiveness of genotype-resistance testing before first-line ART initiation in Brazil.

Design

We used a previously published microsimulation model of HIV disease (CEPAC-International) and data from Brazil to compare the clinical impact, costs, and cost-effectiveness of initial genotype testing (Genotype) with no initial genotype testing (No genotype).

Methods

Model parameters were derived from the HIV Clinical Cohort at the Evandro Chagas Clinical Research Institute and from published data, using Brazilian sources whenever possi

SUBMITTER: Luz PM 

PROVIDER: S-EPMC4294967 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature