Human papillomavirus genotype-specific prevalence across the continuum of cervical neoplasia and cancer.

ABSTRACT:

Background

The New Mexico HPV Pap Registry was established to measure the impact of cervical cancer prevention strategies in the United States. Before widespread human papillomavirus (HPV) vaccine implementation, we established the baseline prevalence for a broad spectrum of HPV genotypes across the continuum of cervical intraepithelial neoplasia (CIN) and cancer.

Methods

A population-based sample of 6,272 tissue specimens was tested for 37 HPV genotypes. The number of specimens tested within each diagnostic category was: 541 negative, 1,411 CIN grade 1 (CIN1), 2,226 CIN grade 2 (CIN2), and 2,094 CIN grade 3 (CIN3) or greater. Age-specific HPV prevalence was estimated within categories for HPV genotypes targeted by HPV vaccines.

Results

The combined prevalence of HPV

SUBMITTER: Joste NE 

PROVIDER: S-EPMC4294978 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature