Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons.

ABSTRACT: Competition between synapses contributes to activity-dependent refinement of the nervous system during development. Does local competition between neighboring synapses drive circuit remodeling during experience-dependent plasticity in the cerebral cortex? Here, we examined the role of activity-mediated competitive interactions in regulating dendritic spine structure and function on hippocampal CA1 neurons. We found that high-frequency glutamatergic stimulation at individual spines, which leads to input-specific synaptic potentiation, induces shrinkage and weakening of nearby unstimulated synapses. This heterosynaptic plasticity requires potentiation of multiple neighboring spines, suggesting that a local threshold of neural activity exists beyond which inactive synapses are punished. Notab

SUBMITTER: Oh WC 

PROVIDER: S-EPMC4294981 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature