Antiinflammatory effect of sevoflurane in open lung surgery with one-lung ventilation.

ABSTRACT:

Aim

To prospectively assess the antiinflammatory effect of volatile anesthetic sevoflurane in patients undergoing open lung surgery with one lung ventilation (OLV).

Methods

This prospective, randomized study included 40 patients undergoing thoracic surgery with OLV (NCT02188407). The patients were randomly allocated into two equal groups that received either propofol or sevoflurane. Four patients were excluded from the study because after surgery they received blood transfusion or non-steroid antiinflammatory drugs. Inflammatory mediators (interleukins 6, 8, and 10, C-reactive protein [CRP], and procalcitonin) were measured perioperatively. The infiltration of the nonoperated lung was assessed on chest x-rays and the oxygenation index was calculated. The major postoperative

SUBMITTER: Potocnik I 

PROVIDER: S-EPMC4295075 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature