Karyotype versus microarray testing for genetic abnormalities after stillbirth.

ABSTRACT:

Background

Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions and duplications called copy-number variants.

Methods

The Stillbirth Collaborative Research Network conducted a population-based study of stillbirth in five geographic catchment areas. Standardized postmortem examinations and karyotype analyses were performed. A single-nucleotide polymorphism array was used to detect copy-number variants of at least 500 kb in placental or fetal tissue. Variants that were not identified in any of three databases of apparently unaffected persons were then classified into three groups: probably benign, clinical signifi

SUBMITTER: Reddy UM 

PROVIDER: S-EPMC4295117 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature