Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood.

ABSTRACT:

Background and purpose

Diffusion tensor imaging (DTI) can noninvasively quantify white matter (WM) integrity. Although its application in adult traumatic brain injury (TBI) is common, few studies in children have been reported. The purposes of this study were to examine the alteration of fractional anisotropy (FA) in children with TBI experienced during early childhood and to quantify the association between FA and injury severity.

Materials and methods

FA was assessed in 9 children with TBI (age = 7.89 +/- 1.00 years; Glasgow Coma Scale [GCS] = 10.11 +/- 4.68) and a control group of 12 children with orthopedic injuries without central nervous system involvement (age = 7.51 +/- 0.95 years). All of the subjects were at minimum 12 months after injury. We examined group differe

SUBMITTER: Yuan W 

PROVIDER: S-EPMC4295209 | biostudies-literature | 2007 Nov-Dec

REPOSITORIES: biostudies-literature