Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib.

ABSTRACT:

Background

Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on differential responses between tumor and normal endothelial cells has not been tested.

Methods

We isolated and characterized three lines of endothelial cells from prostate cancer and we tested the effect of Sunitinib and Sorafenib, and the combined treatment with the anti-androgen Casodex, on their angiogenic functions.

Results

Endothelial cells isolated from prostate tumors showed angiogenic properties and expression of androgen and vascular endothelial cell growth factor receptors. Sunitinib affected thei

SUBMITTER: Fiorio Pla A 

PROVIDER: S-EPMC4295225 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature