Ultrafiltration biofeedback guided by blood volume monitoring to reduce intradialytic hypotensive episodes in hemodialysis: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Fluid removal during dialysis, also known as ultrafiltration (UF), leads to intradialytic hypotension (IDH) in a significant number of patients treated with hemodialysis (HD) and is associated with an increase in morbidity and mortality. At present, there are no accepted standards of practice for the prevention or treatment of IDH. Relative blood volume monitoring (BVM) is based on the concept that the hematocrit increases with UF, relative to the patient's baseline hematocrit. The use of BVM biofeedback, whereby the HD machine automatically adjusts the rate of UF based on the relative blood volume, has been proposed for the prevention of IDH.

Methods/design

This is a 22-week randomized crossover trial. Participants undergo a 4-week run-in phase to standardize med

SUBMITTER: Leung KC 

PROVIDER: S-EPMC4295273 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature