Glutamic acid decarboxylase 1 alternative splicing isoforms: characterization, expression and quantification in the mouse brain.

ABSTRACT:

Background

GABA has important functions in brain plasticity related processes like memory, learning, locomotion and during the development of the nervous system. It is synthesized by the glutamic acid decarboxylase (GAD). There are two isoforms of GAD, GAD1 and GAD2, which are encoded by different genes. During embryonic development the transcription of GAD1 mRNA is regulated by alternative splicing and several alternative transcripts were distinguished in human, mouse and rat. Despite the fact that the structure of GAD1 gene has been extensively studied, knowledge of its exact structural organization, alternative promoter usage and splicing have remained incomplete.

Results

In the present study we report the identification and characterization of novel GAD1 splicing isoform

SUBMITTER: Trifonov S 

PROVIDER: S-EPMC4295415 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature