Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease.

ABSTRACT: Factor XIII (FXIII) is necessary for cross linking of fibrin strands and generation of stable fibrin clot. FXIII Val34Leu is a common genetic single nucleotide polymorphism that has been associated with accelerated fibrin stabilization and reduced rate of fibrinolysis. The contribution of Val34Leu to long term risk of recurrent myocardial infarction (MI) in patients with coronary stenting has not been conclusively established. The objective of the study was to examine the effects of Val34Leu on fibrin generation, platelet aggregation, and long term clinical outcomes in patients with coronary artery disease treated with dual antiplatelet therapy. Patients with angiographically documented coronary artery disease who were treated with aspirin and clopidogrel were enrolled (n = 211). Light tra

SUBMITTER: Kreutz RP 

PROVIDER: S-EPMC4295494 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature