Metabolic syndrome and risk of endometrial cancer in the united states: a study in the SEER-medicare linked database.

ABSTRACT:

Background

Metabolic syndrome and its component feature, central obesity, are associated with endometrial cancer risk. It remains unclear whether associations with the other metabolic factors that comprise metabolic syndrome are independent of the obesity-endometrial cancer association. Furthermore, the link with specific endometrial cancer subtypes remains ill-defined, despite evidence of etiologic heterogeneity among these tumors.

Methods

In a case-control study within the SEER-Medicare linked database, we examined whether metabolic factors, individually or combined, were associated with endometrial cancer. Cases (n = 16,323) were women diagnosed with endometrial cancer from 1993 through 2007. Controls (n = 100,751) were a 5% sample of female Medicare enrollees residing in

SUBMITTER: Trabert B 

PROVIDER: S-EPMC4295647 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature