System model network for adipose tissue signatures related to weight changes in response to calorie restriction and subsequent weight maintenance.

ABSTRACT: Nutrigenomics investigates relationships between nutrients and all genome-encoded molecular entities. This holistic approach requires systems biology to scrutinize the effects of diet on tissue biology. To decipher the adipose tissue (AT) response to diet induced weight changes we focused on key molecular (lipids and transcripts) AT species during a longitudinal dietary intervention. To obtain a systems model, a network approach was used to combine all sets of variables (bio-clinical, fatty acids and mRNA levels) and get an overview of their interactions. AT fatty acids and mRNA levels were quantified in 135 obese women at baseline, after an 8-week low calorie diet (LCD) and after 6 months of ad libitum weight maintenance diet (WMD). After LCD, individuals were stratified a posteriori acco

SUBMITTER: Montastier E 

PROVIDER: S-EPMC4295881 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature