Brain edema predicts outcome after nonlacunar ischemic stroke.

ABSTRACT:

Background and purpose

In malignant infarction, brain edema leads to secondary neurological deterioration and poor outcome. We sought to determine whether swelling is associated with outcome in smaller volume strokes.

Methods

Two research cohorts of acute stroke subjects with serial brain MRI were analyzed. The categorical presence of swelling and infarct growth was assessed on diffusion-weighted imaging (DWI) by comparing baseline and follow-up scans. The increase in stroke volume (ΔDWI) was then subdivided into swelling and infarct growth volumes using region-of-interest analysis. The relationship of these imaging markers with outcome was evaluated in univariable and multivariable regression.

Results

The presence of swelling independently predicted worse outcome aft

SUBMITTER: Battey TW 

PROVIDER: S-EPMC4295905 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature