Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity.

ABSTRACT:

Background

Neuropeptide Y (NPY) is a hypothalamic neuropeptide that plays a prominent role in feeding and energy homeostasis. Expression of the NPY Y1 receptor (Y1R) is highly concentrated in the nucleus accumbens (Acb), a region important in the regulation of palatable feeding. In this study, we performed a number of experiments to investigate the actions of NPY in the Acb.

Methods

First, we determined caloric intake and food choice after bilateral administration of NPY in the Acb in rats on a free-choice diet of saturated fat, 30% sucrose solution, and standard chow and whether this was mediated by the Y1R. Second, we measured the effect of intra-Acb NPY on neuronal activity using in vivo electrophysiology. Third, we examined co-localization of Y1R with enkephalin and dyno

SUBMITTER: van den Heuvel JK 

PROVIDER: S-EPMC4295932 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature