Organic cation transporter variation and response to smoking cessation therapies.

ABSTRACT:

Introduction

We evaluated chr6q25.3 organic cation transporter gene (SLC22A1, SLC22A2, SLC22A3) variation and response to smoking cessation therapies. The corresponding proteins are low-affinity transporters of choline, acetylcholine and monoamines, and smoking cessation pharmacotherapies expressed in multiple tissues.

Methods

We selected 7 common polymorphisms for mega-regression analysis. We assessed additive model association of polymorphisms with 7-day point prevalence abstinence overall and by assigned pharmacotherapy at end of treatment and at 6 months among European-ancestry participants of 7 randomized controlled trials adjusted for demographic, population genetic, and trial covariates.

Results

Initial results were obtained in 6 trials with 1,839 participants.

SUBMITTER: Bergen AW 

PROVIDER: S-EPMC4296186 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature