Risk-benefit profiles of women using tamoxifen for chemoprevention.

ABSTRACT:

Background

Tamoxifen has been US Food and Drug Administration-approved for primary prevention of breast cancer since 1998 but has not been widely adopted, in part because of increased risk of serious side effects. Little is known about the risk-benefit profiles of women who use chemoprevention outside of a clinical trial. We examined characteristics associated with initiation and discontinuation of tamoxifen for primary prevention of breast cancer within a large cohort of women with a first-degree family history of breast cancer.

Methods

This research was conducted within The Sister Study, a cohort of 50884 US and Puerto Rican women age 35 to 74 years enrolled from 2003 to 2009. Eligible women were breast cancer-free at enrollment and had a sister who had been diagnosed with

SUBMITTER: Nichols HB 

PROVIDER: S-EPMC4296193 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature