Gene-environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy.

ABSTRACT:

Aims/introduction

To evaluate whether the adiponectin gene is associated with diabetic retinopathy (DR) risk and interaction with environmental factors modifies the DR risk, and to investigate the relationship between serum adiponectin levels and DR.

Materials and methods

Four adiponectin polymorphisms were evaluated in 372 DR cases and 145 controls. Differences in environmental factors between cases and controls were evaluated by unconditional logistic regression analysis. The model-free multifactor dimensionality reduction method and traditional multiple regression models were applied to explore interactions between the polymorphisms and environmental factors.

Results

Using the Bonferroni method, we found no significant associations between four adiponectin polymorp

SUBMITTER: Li Y 

PROVIDER: S-EPMC4296704 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature