Fecal microbiota transplantation as therapy for inflammatory bowel disease: a systematic review and meta-analysis.

ABSTRACT:

Background and aims

Fecal microbiota transplantation (FMT) has gained interest as a novel treatment option for inflammatory bowel diseases (IBD). While publications describing FMT as therapy for IBD have more than doubled since 2012, research that investigates FMT treatment efficacy has been scarce. We conducted a systematic review and meta-analysis to evaluate the efficacy of FMT as treatment for patients with IBD.

Methods

A systematic literature search was performed through May 2014. Inclusion criteria required FMT as the primary therapeutic agent. Clinical remission (CR) and/or mucosal healing were defined as primary outcomes. Studies were excluded if they did not report clinical outcomes or included patients with infections.

Results

Eighteen studies (9 cohort stud

SUBMITTER: Colman RJ 

PROVIDER: S-EPMC4296742 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature