Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects.

ABSTRACT:

Purpose

We studied the correlation between outer nuclear layer (ONL) thickness and cone density in normal eyes and eyes with retinitis pigmentosa (RP).

Methods

Spectral-domain optical coherence tomography (SD-OCT) scans were acquired using a displaced pupil entry position of the scanning beam to distinguish Henle's fiber layer from the ONL in 20 normal eyes (10 subjects) and 12 eyes with RP (7 patients). Cone photoreceptors were imaged using adaptive optics scanning laser ophthalmoscopy. The ONL thickness and cone density were measured at 0.5° intervals along the horizontal meridian through the fovea nasally and temporally. The ONL thickness and cone density were correlated using Spearman's rank correlation coefficient r.

Results

Cone densities averaged over the centr

SUBMITTER: Menghini M 

PROVIDER: S-EPMC4296838 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature