Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease.

ABSTRACT:

Objectives

The aim of this study was to investigate the relationship between aquaporin (AQP) water channel expression and the pathological features of early untreated inflammatory bowel disease (IBD) in humans.

Methods

Patients suspected to have IBD on the basis of predefined symptoms, including abdominal pain, diarrhea, and/or blood in stool for more than 10 days, were examined at the local hospital. Colonoscopy with biopsies was performed and blood samples were taken. Patients who did not meet the diagnostic criteria for IBD and who displayed no evidence of infection or other pathology in the gut were included as symptomatic non-IBD controls. AQP1, 3, 4, 5, 7, 8, and 9 messenger RNA (mRNA) levels were quantified in biopsies from the distal ileum and colon by quantitative r

SUBMITTER: Ricanek P 

PROVIDER: S-EPMC4296881 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature