C-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells.

ABSTRACT:

Objective

ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix. ADAMTS-12 is up-regulated during in vitro chondrogenesis and embryonic limb development; however, the regulation of ADAMTS-12 expression in cartilage remains unknown. The transcription factor c-Maf is a member of Maf family of basic ZIP (bZIP) transcription factors. Expression of c-Maf is highest in hypertrophic chondrocytes during embryonic development and postnatal growth. We hypothesize that c-Maf and ADAMTS-12 are co-expressed during chondrocyte differentiation and that c-Maf regulates ADAMTS-12 expression during chondrogenesis.

Design

Promoter analysis and species alignments id

SUBMITTER: Hong E 

PROVIDER: S-EPMC4297105 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature