Unique features of apicoplast DNA gyrases from Toxoplasma gondii and Plasmodium falciparum.

ABSTRACT:

Background

DNA gyrase, an enzyme once thought to be unique to bacteria, is also found in some eukaryotic plastids including the apicoplast of Apicomplexa such as Plasmodium falciparum and Toxoplasma gondii which are important disease-causing organisms. DNA gyrase is an excellent target for antibacterial drugs, yet such antibacterials seem ineffective against Apicomplexa. Characterisation of the apicoplast gyrases would be a useful step towards understanding why this should be so. While purification of active apicoplast gyrase has proved impossible to date, in silico analyses have allowed us to discover differences in the apicoplast proteins. The resulting predicted structural and functional differences will be a first step towards development of apicoplast-gyrase specific inhibitor

SUBMITTER: Nagano S 

PROVIDER: S-EPMC4297366 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature