Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.

ABSTRACT:

Background

In view of previous conflicting findings, this meta-analysis was performed to comprehensively determine the overall strength of associations between brain-derived neurotrophic factor (BDNF) genetic polymorphism Val66Met and susceptibility to bipolar disorders (BPD).

Methods

Literatures published and cited in Pubmed and Wanfang Data was searched with terms of 'Val66Met', 'G196A', 'rs6265', 'BDNF', 'association', and 'bipolar disorder' up to March 2014. All original case-control association studies were meta-analyzed with a pooled OR to estimate the risk and 95% confidence interval (CI) to reflect the magnitude of variance.

Results

Twenty-one case-control association studies met our criteria for the meta-analysis. Overall, there was no significant difference

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4297385 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature