Iron, inflammation, and early death in adults with sickle cell disease.

ABSTRACT:

Rationale

Patients with sickle cell disease (SCD) have markers of chronic inflammation, but the mechanism of inflammation and its relevance to patient survival are unknown.

Objective

To assess the relationship between iron, inflammation, and early death in SCD.

Methods and results

Using peripheral blood mononuclear cell transcriptome profile hierarchical clustering, we classified 24 patients and 10 controls in clusters with significantly different expression of genes known to be regulated by iron. Subsequent gene set enrichment analysis showed that many genes associated with the high iron cluster were involved in the toll-like receptor system (TLR4, TLR7, and TLR8) and inflammasome complex pathway (NLRP3, NLRC4, and CASP1). Quantitative PCR confirmed this classificati

SUBMITTER: van Beers EJ 

PROVIDER: S-EPMC4297524 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature