Bidirectional promoters of insects: genome-wide comparison, evolutionary implication and influence on gene expression.

ABSTRACT: Bidirectional promoters are widespread in insect genomes. By analyzing 23 insect genomes we show that the frequency of bidirectional gene pairs varies according to genome compactness and density of genes among the species. The density of bidirectional genes expected based on number of genes per megabase of genome explains the observed density suggesting that bidirectional pairing of genes may be due to random event. We identified specific transcription factor binding motifs that are enriched in bidirectional promoters across insect species. Furthermore, we observed that bidirectional promoters may act as transcriptional hotspots in insect genomes where protein coding genes tend to aggregate in significantly biased (p < 0.001) manner compared to unidirectional promoters. Natural selection s

SUBMITTER: Behura SK 

PROVIDER: S-EPMC4297529 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature