Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism.

ABSTRACT:

Purpose

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease that develops relatively symptom-free and is therefore advanced at the time of diagnosis. The absence of early symptoms and effective treatments has created a critical need for identifying and developing new noninvasive biomarkers and therapeutic targets.

Experimental design

We investigated the metabolism of a panel of PDAC cell lines in culture and noninvasively in vivo with (1)H magnetic resonance spectroscopic imaging (MRSI) to identify noninvasive biomarkers and uncover potential metabolic targets.

Results

We observed elevated choline-containing compounds in the PDAC cell lines and tumors. These elevated choline-containing compounds were easily detected by increased total choline (

SUBMITTER: Penet MF 

PROVIDER: S-EPMC4297549 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature