Crosstalk between signaling pathways provided by single and multiple protein phosphorylation sites.

ABSTRACT: Cellular fate depends on the spatiotemporal separation and integration of signaling processes that can be provided by phosphorylation events. In this study, we identify the crucial points in signaling crosstalk that can be triggered by discrete phosphorylation events on a single target protein. We integrated the data on individual human phosphosites with the evidence on their corresponding kinases, the functional consequences of phosphorylation on activity of the target protein and corresponding pathways. Our results show that there is a substantial fraction of phosphosites that can play critical roles in crosstalk between alternative and redundant pathways and regulatory outcome of phosphorylation can be linked to a type of phosphorylated residue. These regulatory phosphosites can serve a

SUBMITTER: Nishi H 

PROVIDER: S-EPMC4297578 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature